Microscale Thermophoresis

Measures binding affinity by tracking how a temperature gradient changes molecular movement, which shifts upon binding.

References

• Wienken, C.J., Baaske, P., Rothbauer, U., Braun, D., Duhr, S. "Protein-Binding Assays in Biological Liquids Using Microscale Thermophoresis." Nature Communications 1 (2010): 100.